Company Filing History:
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Years Active: 1995-2005
Title: Bradford A. Jameson: Innovator in Immunomodulation and T Cell Activation
Introduction
Bradford A. Jameson is a prominent inventor based in Philadelphia, PA, known for his significant contributions to the field of immunology. With a total of 10 patents to his name, he has made remarkable strides in understanding and manipulating immune responses, particularly through the modulation of serotonin receptors.
Latest Patents
One of his latest patents focuses on immunomodulation and its effects on cell processes related to serotonin family receptors. This invention reveals that signaling via serotonin type 1B, 2, 4, and 6 receptors plays a crucial role in T cell activation. By inhibiting this signaling, it is possible to modulate the immune response, which can be beneficial for treating various immune diseases. Furthermore, it has been discovered that inhibiting serotonin signaling during the cell cycle can induce apoptosis and morphological changes in cells, paving the way for selective cell killing and the identification of compounds that inhibit this signaling.
Another notable patent involves CD8 antagonists, which are compounds that inhibit CD8-mediated T cell activation. These compounds correspond to specific molecular surfaces of human CD8 and are essential for developing pharmaceutical compositions aimed at treating conditions such as graft versus host disease and organ rejection.
Career Highlights
Bradford A. Jameson has worked with esteemed institutions such as Thomas Jefferson University and Temple University. His research has significantly advanced the understanding of immune responses and therapeutic approaches to immune-related conditions.
Collaborations
Throughout his career, Jameson has collaborated with notable colleagues, including Robert Korngold and James M. McDonnell. These partnerships have contributed to the innovative research and development of his patented technologies.
Conclusion
Bradford A. Jameson stands out as a key figure in the field of immunology, with his inventions paving the way for new therapeutic strategies. His work continues to influence the understanding of immune modulation and T cell activation, showcasing the importance of innovation in medical research.