The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2005
Filed:
Mar. 29, 2002
Bradford A. Jameson, Philadelphia, PA (US);
Anna A. Tretiakova, Philadelphia, PA (US);
Ross Albert, Philadelphia, PA (US);
Harold Carter Davidson, Philadelphia, PA (US);
Bradford A. Jameson, Philadelphia, PA (US);
Anna A. Tretiakova, Philadelphia, PA (US);
Ross Albert, Philadelphia, PA (US);
Harold Carter Davidson, Philadelphia, PA (US);
Philadelphia Health and Education Corporation, Philadelphia, PA (US);
Abstract
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile