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For the Inventor, By the Inventor

Raleigh, NC, United States of America

Bernard F Spielvogel

This inventor holds 27 USPTO granted patents, primarily in Boron Chemistry. Top assignees: Boron Biologicals, Inc., Duke University, US Government as Represented by the Secretary of the Army. Active years: 1980-1997.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Bernard F Spielvogel. Retrieved from https://idiyas.com/inventor/bernard-f-spielvogel

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 27

% Patents Active = 100.0

Average Co-Inventor Count = 2.4

ph-index = 12

Forward Citations = 1,604(Granted Patents)


Location History:

  • Durham, NC (US) (1980 - 1983)
  • Wake, NC (US) (1987)
  • Wake County, NC (US) (1987)
  • Raleigh, NC (US) (1985 - 1997)
  • Cary, NC (US) (1993 - 1997)

Company Filing History:

goldMedal15 out of 15 
 
Boron Biologicals, Inc.
 patents
silverMedal6 out of 2,085 
 
Duke University
 patents
bronzeMedal6 out of 8,753 
 
US Government as Represented by the Secretary of the Army
 patents
4. 4 out of 1,329 
 
The University of North Carolina at Chapel Hill
 patents
5. 1 out of 1 
 
Boron Bilogicals, Inc.
 patent
6. 1 out of 1 
 
Boron Biolgicals, Inc.
 patent
7. 1 out of 25 
 
Guerbet S.a.
 patents
8. 1 out of 16,283 
 
USA as Represented by Secretary of the Navy
 patents
9. 1 out of 834,570 
Other
 patents
where one patent can have more than one assignee

Years Active: 1980-1997

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Areas of Expertise:
Boronated Compounds
Phosphite-Borane Compounds
Radiological Imaging
Biopolymers
Biooligomers
Pharmaceutical Compositions
Oligonucleotide Compounds
DNA Topoisomerase
Contrast Agents
Boron-Gadolinium Compounds
Heterocyclic Amines
Amine-Carboxyboranes
27 patents (USPTO):Explore Patents
1. 5659027 - Boronated compounds (1997-08-19),
2. 5595878 - Detection of biopolymers and biooligomers with boron hydride labels (1997-01-21),
3. 5545397 - Contrast agents and compositions for radiological imaging, and (1996-08-13),
4. 5455233 - Oligoribonucleoside and oligodeoxyribonucleoside boranophosphates (1995-10-03),
5. 5434143 - Pharmaceutical compositions comprising phosphite-borane compounds (1995-07-18),
6. 5399732 - Phosphite-borane compounds, and method of making and using the same (1995-03-21),
7. 5362732 - Boronated compounds (1994-11-08),
8. 5312816 - Method of combatting osteoporosis in mammalian subjects, utilizing (1994-05-17),
9. 5286853 - Boron-gadolinium compounds and method of conducting imaging and/or (1994-02-15),
10. 5280119 - Heterocyclic amine-boranes, and method of inhibiting DNA topoisomerase (1994-01-18),
11. 5272250 - Boronated phosphoramidate compounds (1993-12-21),
12. 5260427 - Nucleosidylphosphite-borane compounds and method of making the same (1993-11-09),
13. 5256394 - Radiological imaging method, and contrast media reagents therefor (1993-10-26),
14. 5254706 - Process of making phosphite-borane compounds (1993-10-19),
15. 5177198 - Process for preparing oligoribonucleoside and oligodeoxyribonucleoside (1993-01-05),

Title: Innovations by Bernard F. Spielvogel: A Pioneer in Boronated Compounds

Introduction: Bernard F. Spielvogel, a prominent inventor based in Raleigh, NC, is known for his groundbreaking contributions to the field of pharmaceuticals and biochemistry. With a remarkable portfolio of 27 patents, Spielvogel has significantly advanced the understanding and application of boronated compounds.

Latest Patents: Among his latest inventions are novel classes of pharmaceutically active boronated compounds. These compounds comprise boronated purine and pyrimidine bases, as well as boronated nucleosides, alongside phosphate esters and their oligomers. These substances have boron inserted at specific sites, enhancing their utility in medical applications. Another notable patent focuses on the detection of biopolymers and biooligomers with boron hydride labels. This innovative method allows for the detection of RNA, DNA, and proteins that bind with boron-labeled biopolymers, enabling selective identification in environments filled with both labeled and unlabeled species.

Career Highlights: Spielvogel's professional journey includes collaborations with esteemed organizations like Boron Biologicals, Inc. and the United States of America as represented by the Secretary of the Army. His work has garnered attention and respect in the scientific community, marking him as a leading inventor in his domain.

Collaborations: Throughout his career, Bernard F. Spielvogel has worked alongside notable colleagues such as Anup Sood and Iris H. Hall. Their collaborative efforts have helped achieve significant advancements in the research and development of boronated compounds, further enhancing the therapeutic potential within biomedical fields.

Conclusion: Bernard F. Spielvogel's innovative work in the realm of boronated compounds not only showcases his dedication to scientific advancement but also supports the growth of therapeutic applications. With 27 patents to his name and a history of impactful collaborations, Spielvogel continues to be a key figure in the development of novel pharmaceutical solutions.

Profile summary based on public USPTO records.
Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]
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