Location History:
- Phoenixville, PA (US) (2010)
- Radnor, PA (US) (2015)
Company Filing History:
Years Active: 2010-2015
Title: Innovations in Antibody Discovery: The Work of Bernard Amegadzie
Introduction
Bernard Amegadzie, based in Radnor, Pennsylvania, is a noteworthy inventor contributing to the field of antibody discovery. With his expertise in biotechnology, Amegadzie has made significant strides that enhance the efficiency and specificity of antibody development, which are crucial for therapeutic applications.
Latest Patents
Amegadzie holds a patent that describes combinatorial synthetic Fab libraries displayed on a phage pIX protein. These libraries leverage scaffolds that embody the most frequently utilized genes in human antibodies, diversifying to reflect the natural variability found in antibodies. After selection through a diverse panel of proteins, he succeeded in isolating numerous specific and high-affinity Fabs. Notably, through a process known as in-line maturation, the affinity of certain antibodies was enhanced by up to one hundred-fold, producing low picomolar binders that are suitable for in vivo applications. This work not only demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins but also lays the groundwork for future studies on the structure-function relationship of antibodies.
Career Highlights
Currently, Amegadzie is employed at Janssen Biotech, Inc., where he continues to push the boundaries of antibody research and development. His innovative approaches aim to address complex challenges in therapeutic applications, making considerable contributions to the biotechnology sector.
Collaborations
Amegadzie works alongside esteemed colleagues, including Ping Tsui and Lei Shi, fostering a collaborative environment that drives forward the mission of their research initiatives. Together, they engage in groundbreaking projects that harness their collective expertise to enhance the field of antibody discovery.
Conclusion
Through his innovative patent and ongoing work at Janssen Biotech, Bernard Amegadzie exemplifies the spirit of invention in the biotechnology industry. His contributions not only advance the science of antibody discovery but also underline the importance of collaboration within the research community, promising advancements that could benefit therapeutic practices in the future.