Barton Holmquist

Title: The Innovative Contributions of Barton Holmquist

Introduction

Barton Holmquist is a notable inventor based in Eagle, Nebraska, who has made significant contributions to the field of peptide chemistry. With a total of 10 patents to his name, Holmquist has developed innovative processes that enhance the understanding and application of polypeptide cleavage.

Latest Patents

Among his latest patents is a groundbreaking method titled "Polypeptide cleavage process." This invention describes a palladate palladium-promoted hydrolytic polypeptide cleavage process that selectively cleaves polypeptides at a Cys-His cleavage site. The process involves solubilizing the polypeptide in a reaction mixture that contains a palladate palladium promoter dissolved in a high-concentration acidic organic acid solvent. Another significant patent is the "Composition for palladium-mediated cleavage of peptides containing CXC, CXH or CHM sequences." This invention outlines a process for amidating a desired peptide by cleaving a substrate polypeptide at an X-cysteine sequence, where X represents the amino acid at the peptide carboxyl-terminus.

Career Highlights

Throughout his career, Barton Holmquist has worked with prominent companies such as Restoragen, Inc. and Medtronic, Inc. His work in these organizations has allowed him to apply his innovative ideas in practical settings, contributing to advancements in medical and biochemical applications.

Collaborations

Holmquist has collaborated with several talented individuals in his field, including Daniel J. Strydom and Jin Seog Seo. These collaborations have likely enriched his research and development efforts, leading to the successful patents he holds today.

Conclusion

Barton Holmquist's contributions to peptide chemistry through his innovative patents demonstrate his expertise and commitment to advancing the field. His work continues to influence the development of new technologies and processes in biochemistry.