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Title: Bartholomeus Johannes Van Steen: Innovator in Steroid Hormone Research
Introduction
Bartholomeus Johannes Van Steen is a notable inventor based in Utrecht, Netherlands. He has made significant contributions to the field of steroid hormone research, particularly through his innovative patents. With a total of two patents to his name, Van Steen's work focuses on the development of compounds that can inhibit specific enzymes related to steroid hormone-dependent diseases.
Latest Patents
Van Steen's latest patents include the development of 17β-hydroxysteroid dehydrogenase type I inhibitors. These inhibitors consist of 3,15-substituted estrone compounds that act as inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1). The patents detail the salts of these compounds, pharmaceutical preparations containing them, and the processes for preparing such compounds. They also explore the therapeutic uses of these compounds, particularly in treating or inhibiting steroid hormone-dependent diseases or disorders. This includes conditions that require the inhibition of 17β-hydroxysteroid dehydrogenase type I enzymes and the lowering of endogenous 17β-estradiol concentration. Additionally, the patents discuss the use of selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors that possess minimal or pure antagonistic binding affinities to the estrogen receptor for treating benign gynecological disorders, especially endometriosis. Another patent focuses on thiophenepyrimidinone compounds and their therapeutic applications in treating steroid hormone-dependent diseases.
Career Highlights
Throughout his career, Bartholomeus Johannes Van Steen has worked with prominent companies in the pharmaceutical industry, including Solvay Pharmaceuticals B.V. and Solvay Pharmaceuticals GmbH. His work in these organizations has allowed him to contribute to significant advancements in the field of hormone research.
Collaborations
Van Steen has collaborated with notable colleagues, including Nina Johansson and Pasi Koskimies. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the impact of his research.
Conclusion
Bartholomeus Johannes Van Steen is a distinguished inventor whose work in steroid hormone research has led to valuable patents and therapeutic advancements. His contributions continue to influence the treatment of hormone-dependent diseases, showcasing the importance of innovation in the medical field.