The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 03, 2012

Filed:

Nov. 09, 2004
Applicants:

Josef Messinger, Sehnde, DE;

Heinrich-hubert Thole, Hannover, DE;

Bettina Husen, Hannover, DE;

Bartholomeus Johannes Van Steen, Utrecht, NL;

Gyula Schneider, Szeged, HU;

Johannes Bernardus Everardus Hulshof, VH Eelde, NL;

Pasi Koskimies, Turku, FI;

Nina Johansson, Turku, FI;

Jerzy Adamski, Munich, DE (US);

Inventors:

Josef Messinger, Sehnde, DE;

Heinrich-Hubert Thole, Hannover, DE;

Bettina Husen, Hannover, DE;

Bartholomeus Johannes Van Steen, Utrecht, NL;

Gyula Schneider, Szeged, HU;

Johannes Bernardus Everardus Hulshof, VH Eelde, NL;

Pasi Koskimies, Turku, FI;

Nina Johansson, Turku, FI;

Jerzy Adamski, Munich, DE (US);

Assignee:

Abbott Products GmbH, Hannover, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/58 (2006.01); C07J 1/00 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

3,15-substituted estrone compounds which act as inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1), salts thereof, pharmaceutical preparations containing such compounds, processes for preparing such compounds, and therapeutic uses of such compounds, particularly in the treatment or inhibition of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid dehydrogenase type I enzymes and/or requiring the lowering of the endogenous 17β-estradiol concentration, as well as the general use of selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors which possess in addition no or only pure antagonistic binding affinities to the estrogen receptor for the treatment or inhibition of benign gynecological disorders, particularly endometriosis.


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