Solvay Pharmaceuticals, Gmbh

Solvay Pharmaceuticals, B.v.

Abbott Products Gmbh

Bartholomeus Johannes Van Steen

Pasi Koskimies

Josef Messinger

Heinrich-Hubert Thole

Bettina Husen

Nina Johansson

Mikko Unkila

Lila Pirkkala

Mark Stuart Johnson

Tiina Annamaria Salminen

Leena Hirvelae

Pekka Lehtovuori

Tommi Nyroenen

Olli Taneli Pentikaeinen

Jerzy Adamski

Johannes Bernardus Everardus Hulshof

Gyula Schneider

Pauli Saarenketo

Johanna Kiviniemi

Johannes Bernardus Hulshof

3,15-substituted estrone compounds which act as inhibitors of 17&#x3b2;-hydroxysteroid dehydrogenase type I (17&#x3b2;-HSD1), salts thereof, pharmaceutical preparations containing such compounds, processes for preparing such compounds, and therapeutic uses of such compounds, particularly in the treatment or inhibition of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17&#x3b2;-hydroxysteroid dehydrogenase type I enzymes and/or requiring the lowering of the endogenous 17&#x3b2;-estradiol concentration, as well as the general use of selective 17&#x3b2;-hydroxysteroid dehydrogenase type 1 inhibitors which possess in addition no or only pure antagonistic binding affinities to the estrogen receptor for the treatment or inhibition of benign gynecological disorders, particularly endometriosis.

17&#x3b2;-hydroxysteroid dehydrogenase type I inhibitors

Thiophenepyrimidinone compounds and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring inhibition of 17&#x3b2;-hydroxysteroid dehydrogenase enzymes.

Compounds and their use in therapy

Growing community of inventors

Utrecht, Netherlands

Bartholomeus Johannes Van Steen