Company Filing History:
9 out of 2,597 
2 out of 3,923 
Years Active: 2017-2025
Title: **Innovator Spotlight: Avery D. Posey**
Introduction
Avery D. Posey is an accomplished inventor based in Philadelphia, PA, holding an impressive portfolio of 9 patents. Her groundbreaking work primarily focuses on developing innovative therapies aimed at treating various cancers through advanced chimeric antigen receptor (CAR) T cell technologies.
Latest Patents
Avery’s latest patents demonstrate her pioneering contributions to cancer treatment methodologies. One notable invention is titled "Use of the CD2 signaling domain in second-generation chimeric antigen receptors." This invention encompasses compositions and methods for treating cancer in humans, which includes administering genetically modified T cells that express a CAR with an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also explores incorporating CD2 into the CAR to modify cytokine production of CAR-T cells both positively and negatively.
Another significant patent is "Use of CD2/5/7 knock-out anti-CD2/5/7 chimeric antigen receptor T cells against T cell lymphomas and leukemias." This invention includes methods and compositions for treating T cell lymphomas and leukemias, with a focus on CAR T cells targeting CD2, CD5, or CD7 and modified cells where CD2, CD5, or CD7 has been knocked out.
Career Highlights
Avery has had a significant impact in her field through her roles at prestigious organizations, including the University of Pennsylvania and Novartis AG. Her work at these institutions has not only contributed to her collection of patents but has also pushed the boundaries of cancer research and treatment.
Collaborations
Throughout her career, Avery has collaborated with notable figures in the field, including Carl H. June and John Scholler. These collaborations have fostered an environment of innovation and have facilitated the development of cutting-edge therapies that harness the potential of modified T cells.
Conclusion
Avery D. Posey is a leading figure in the field of cancer research and treatment, with a commitment to advancing therapeutic technologies through her numerous patents and collaborations. Her work continues to inspire and pave the way for future innovations in cancer therapy, making her an exemplary inventor in the medical field.