The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Feb. 22, 2013
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Carl H. June, Merion Station, PA (US);
John Scholler, Narberth, PA (US);
Avery D. Posey, Jr., Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 15/85 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 14/705 (2013.01); C07K 14/70507 (2013.01); C07K 16/2803 (2013.01); C07K 16/30 (2013.01); C12N 15/85 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01);
Abstract
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.