The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Jan. 15, 2016
Novartis Ag, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Jennifer Brogdon, Cambridge, MA (US);
Hilmar Erhard Ebersbach, Basel, CH;
David Glass, Cambridge, MA (US);
Thomas Huber, Basel, CH;
Julia Jascur, Basel, CH;
Carl H. June, Merion Station, PA (US);
Jihyun Lee, Wynnewood, PA (US);
Joan Mannick, Cambridge, MA (US);
Michael C. Milone, Cherry Hill, NJ (US);
Leon Murphy, Cambridge, MA (US);
Avery D. Posey, Philadelphia, PA (US);
Huijuan Song, Shanghai, CN;
Yongqiang Wang, Shanghai, CN;
Lai Wei, Shanghai, CN;
Qilong Wu, Brighton, MA (US);
Qiumei Yang, Shanghai, CN;
Jiquan Zhang, Shanghai, CN;
Novartis AG, Basel, CH;
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Abstract
The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.