This inventor holds 3 USPTO granted patents. Top assignee: Hemarus Therapeutics Limited. Active years: 2017-2018.
Company Filing History:
Years Active: 2017-2018
Title: Innovations by Ashok Kumar Nuvula in Therapeutic Proteins
Introduction
Ashok Kumar Nuvula is an innovative inventor based in Hyderabad, Telangana, India. He has made significant contributions to the field of biotechnology with a focus on enhancing the production of therapeutic proteins. With a portfolio of three patents, Ashok’s work aims to improve therapeutic applications derived from human plasma.
Latest Patents
Ashok Kumar Nuvula's latest patents include two noteworthy inventions:
1. **Chromatographic process for producing high purity fibrinogen and thrombin**: This invention pertains to a chromatographic method for obtaining purified forms of fibrinogen and thrombin from human plasma. The developed process ensures that the purified preparations contain plasminogen in amounts less than 1 µg/mL. The low concentration of plasminogen helps eliminate the need for a proteolytic inhibitor, such as aprotinin, in fibrin sealant kits used for human therapeutic applications.
2. **Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma**: This invention presents an integrated procedure for isolating and purifying various plasma-derived proteins, including clotting factors VIII and IX, albumin, and immunoglobulin, without the use of ethanol precipitation. The method employs sequential chromatography steps—gel filtration, anion exchange, and cation exchange—followed by viral inactivation and removal processes. This innovative approach is designed to maintain protein integrity without denaturing or aggregating the components, yielding high amounts of therapeutic-grade plasma proteins from a single volume of plasma.
Career Highlights
Ashok Kumar Nuvula's career is marked by his dedication to advancing biopharmaceutical technologies. His expertise and innovative methodologies have positioned him as a valuable asset in the industry, particularly in efforts to enhance the safety and efficacy of therapeutics derived from human plasma.
Collaborations
In his professional journey, Ashok has collaborated with notable coworkers, including Zinia Chakraborty and Uma Devi Komath. Their combined expertise contributes to the ongoing innovation and development of new methods for therapeutic protein production.
Conclusion
With a strong emphasis on innovation in biotechnology, Ashok Kumar Nuvula continues to lead advancements in the purification and application of therapeutic proteins. His patents reflect a commitment to improving human health through scientific discovery and process optimization in the biopharmaceutical industry.