Location History:
- Temple, TX (US) (2010 - 2019)
- Dallas, TX (US) (2021)
Company Filing History:
7 out of 8 
2 out of 3,435 
2 out of 22 
Years Active: 2010-2024
Title: The Innovative Contributions of Arthur E. Frankel
Introduction
Arthur E. Frankel is a notable inventor based in Temple, Texas, who has made significant contributions to the field of medical science. With a total of 11 patents to his name, Frankel's work primarily focuses on innovative methods and compositions that utilize diphtheria toxin-interleukin-3 conjugates. His inventions aim to address critical health challenges, particularly in the realm of cancer treatment.
Latest Patents
Frankel's latest patents include groundbreaking methods for inhibiting interleukin-3 receptor-expressing cells. One of his notable inventions involves a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. This conjugate is designed as a fusion protein that combines specific amino acids of diphtheria toxin with full-length human interleukin-3. The methods outlined in his patents focus on administering the DT-IL3 conjugate to inhibit the growth of cancer cells and cancer stem cells in humans. These cells often express one or more subunits of the interleukin-3 receptor, making them targets for this innovative treatment. Additionally, Frankel's methods include ex vivo purging of bone marrow or peripheral blood to remove these harmful cells, thereby making the purged material suitable for autologous stem cell transplantation.
Career Highlights
Throughout his career, Frankel has worked with esteemed organizations such as Scott & White Memorial Hospital and the National Institutes of Health, which is a component of the U.S. Department of Health & Human Services. His experience in these institutions has allowed him to develop and refine his innovative approaches to medical treatment.
Collaborations
Frankel has collaborated with notable colleagues in his field, including Yunpeng Su and Brad St. Croix. These partnerships have contributed to the advancement of his research and the successful development of his patented methods.
Conclusion
Arthur E. Frankel's contributions to medical science through his innovative patents demonstrate his commitment to improving cancer treatment. His work with diphtheria toxin-interleukin-3 conjugates represents a significant advancement in the fight against cancer, showcasing the potential of targeted therapies.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.