The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2019
Filed:
Apr. 04, 2016
Applicant:
Scott & White Healthcare, Temple, TX (US);
Inventors:
Arthur E. Frankel, Temple, TX (US);
Yunpeng Su, Katy, TX (US);
Brad St. Croix, Frederick, MD (US);
Stephen H. Leppla, Bethesda, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 9/0019 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61K 47/6809 (2017.08); A61K 47/6811 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/35 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal angiogenesis. In particular, these antibodies detect tumor endothelial marker 8 (TEM8) in its native and cell-surface expressed form. Also disclosed are improved methods for producing monoclonal antibodies, as well as pharmaceutical compositions and kits.