Location History:
- Edina, MN (US) (1987)
- Seattle, WA (US) (1988 - 1998)
Company Filing History:
7 out of 48 
2 out of 3,681 
1 out of 5 Years Active: 1987-1998
Title: **Inventor Profile: Anthony F. Purchio**
Introduction
Anthony F. Purchio is a notable inventor based in Seattle, Washington, renowned for his contributions to biotechnology and molecular biology. With a remarkable portfolio of 13 patents, his work primarily revolves around the expression and modulation of growth factors, significantly impacting cancer research and cell growth modulation.
Latest Patents
Among his latest patents, Purchio has developed techniques for the cloning and expression of simian transforming growth factor beta-1 (TGF-β1). The recombinant TGF-β1 is expressed in high levels within Chinese hamster ovary (CHO) cells through dihydrofolate reductase (dhfr) gene amplification. The expression plasmid derived from pSV2 vectors showcases both simian TGF-β1 and mouse dhfr cDNAs, under the control of the SV40 early promoter. His methods have led to the stepwise selection of transfected CHO cells, resulting in cell lines exhibiting amplified TGF-β1 nucleic acid sequences, with impressive recombinant TGF-β1 protein secreted levels reaching approximately 30 µg per 24 hours from 10^7 cells.
Another significant patent focuses on Oncostatin M and its novel compositions with anti-neoplastic activity. These compositions can be generated from natural sources or through recombinant means in various host cells. The methods outlined by Purchio highlight the utility of these compositions in modulating cell growth, particularly in inhibiting tumor cell proliferation while stimulating normal cell growth associated with hematopoiesis. Furthermore, the patents also discuss high-affinity receptors for Oncostatin M and their potential in screening polypeptides exhibiting Oncostatin M-like activity.
Career Highlights
Throughout his career, Purchio has collaborated with prominent companies in the biotechnology and pharmaceutical sectors, including Oncogen and Bristol-Myers Squibb Company. His work has played an integral role in advancing research methodologies and therapeutic applications within these organizations.
Collaborations
During his tenure in the industry, Purchio has had the opportunity to collaborate with notable colleagues such as Timothy M. Rose and Linda Madisen. These partnerships have contributed to the progress and development of innovative solutions in their respective fields.
Conclusion
Anthony F. Purchio exemplifies an innovative spirit in the field of biotechnology. With numerous patents to his name and impactful collaborations, his contributions continue to enhance our understanding and capabilities in combating various diseases through growth factor modulation and recombinant technologies.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.