Company Filing History:
Years Active: 1994-2008
Title: Innovations of Ann L Lee
Introduction
Ann L Lee is a prominent inventor based in Lansdale, PA (US). She has made significant contributions to the field of biotechnology, particularly in the purification of adenoviruses and plasmid DNA. With a total of three patents to her name, her work has had a substantial impact on the efficiency and effectiveness of viral vector production.
Latest Patents
One of her latest patents is titled "Methods of adenovirus purification." This process focuses on purifying virus particles, especially recombinant adenovirus vector particles. The method utilizes various techniques, including cell lysis, detergent-based precipitation, depth filtration, ultrafiltration, nuclease digestion, and chromatography. This innovative approach ensures that contaminating DNA levels remain consistently below detectable levels.
Another significant patent is the "Method for large scale plasmid purification." This invention describes a process for the large-scale isolation and purification of plasmid DNA from microbial fermentations. The method employs a rapid heating technique to induce cell lysis while preserving the plasmid in solution. This process offers numerous advantages, including higher product recovery, inactivation of DNases, operational simplicity, and scalability.
Career Highlights
Ann L Lee is currently associated with Merck & Company, Inc., where she continues to advance her research and innovations. Her work has been instrumental in enhancing the production processes within the biotechnology sector.
Collaborations
Throughout her career, Ann has collaborated with notable colleagues, including John O Konz, Jr and Chi Shung Brian To. These partnerships have contributed to the success and development of her innovative projects.
Conclusion
Ann L Lee's contributions to biotechnology through her patents and research have significantly advanced the field. Her innovative methods for virus and plasmid purification demonstrate her commitment to improving biotechnological processes.