The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2008
Filed:
May. 13, 2003
John O. Konz, Jr., Erdenheim, PA (US);
Ann L. Lee, Lansdale, PA (US);
Chi Shung Brian to, North Wales, PA (US);
Aaron R Goerke, Schwenksville, PA (US);
John O. Konz, Jr., Erdenheim, PA (US);
Ann L. Lee, Lansdale, PA (US);
Chi Shung Brian To, North Wales, PA (US);
Aaron R Goerke, Schwenksville, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of host cell contaminants away from the virus, depth filtration or centrifugation, ultrafiltration, nuclease digestion and chromatography to robustly and economically produce highly purified product. This process results in contaminating DNA levels which are consistently below detectable levels.