The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 1994
Filed:
Jul. 13, 1992
Applicant:
Inventors:
Ann L Lee, Lansdale, PA (US);
Mark S Rienstra, Lansdale, PA (US);
Walter E Manger, Harleysville, PA (US);
Robert D Sitrin, Lafayette Hill, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12R / ;
U.S. Cl.
CPC ...
435101 ; 435170 ; 435262 ; 435280 ; 536117 ; 5361231 ; 424 88 ; 424 92 ; 210601 ; 210616 ; 210631 ;
Abstract
A process for converting lipid-containing bacterial capsular polysaccharide, such as lipo-polyribosyl ribitol phosphate, lipo-PRP, into lipid-free, endotoxin-free polysaccharide, such as polyribosyl ribitol phosphate, PRP, by solubilizing polysaccharide-containing powder derived from culture media of bacteria, such as Haemophilus influenzae type b, cleaving covalently bound fatty acids from the polysaccharide, and removing the lipids, and endotoxin.