Anindita Basu

Title: Anindita Basu: Innovating Neuroscience Through Novel RNA Sequencing Techniques

Introduction

Anindita Basu is a distinguished inventor based in Cambridge, MA, USA, renowned for her significant contributions to the field of neuroscience. With a remarkable portfolio consisting of five patents, Basu has pioneered innovative methods that advance our understanding of gene expression dynamics in single cells, particularly focusing on adult neurogenesis.

Latest Patents

Basu's latest patents introduce groundbreaking techniques for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells. These methods, known as Nuc-seq, Div-Seq, and Dronc-Seq, allow for unbiased analysis of complex tissues. Nuc-seq is a scalable single nucleus RNA-Seq method that sensitively identifies closely related cell types within the adult hippocampus. Div-Seq combines this with EdU-mediated labeling of proliferating cells, enabling the tracking of transcriptional dynamics of newborn neurons in adult neurogenic regions. Additionally, Dronc-Seq employs a microfluidic device to co-encapsulate individual nuclei in reverse emulsion droplets with uniquely barcoded mRNA-capture beads. This breakthrough led to the discovery of rare adult newborn GABAergic neurons in the spinal cord, signifying a non-canonical neurogenic region.

Career Highlights

Basu has made impactful strides in her career by working with prestigious organizations such as the Broad Institute, Inc. and the Massachusetts Institute of Technology. Her endeavors have propelled advancements in the understanding of neurogenesis, positioning her as a leading figure in her field.

Collaborations

Throughout her career, Basu has collaborated with esteemed professionals, including Aviv Regev and David A Weitz. These collaborations have fostered an environment of innovation, further enhancing the development of her patented technologies.

Conclusion

Anindita Basu's contributions to neuroscience through her pioneering RNA sequencing techniques are invaluable. Her patents not only reflect her expertise but also serve as a vital resource for understanding complex biological processes. With her ongoing efforts in research and innovation, Basu continues to enhance the scientific community's knowledge of gene expression dynamics and neurogenesis.