The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 20, 2024

Filed:

Oct. 28, 2016
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Anindita Basu, Cambridge, MA (US);

Christopher B. Ford, Cambridge, MA (US);

Aviv Regev, Cambridge, MA (US);

David A. Weitz, Cambridge, MA (US);

Asaf Rotem, Boston, MA (US);

Kevin Struhl, Cambridge, MA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); C12M 3/06 (2006.01); G01N 33/50 (2006.01); C12Q 1/02 (2006.01); C12M 1/34 (2006.01); C12Q 1/18 (2006.01); C12M 1/32 (2006.01); B01L 3/02 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01L 3/502746 (2013.01); C12M 23/12 (2013.01); C12M 23/16 (2013.01); C12M 41/46 (2013.01); C12Q 1/025 (2013.01); C12Q 1/18 (2013.01); G01N 33/502 (2013.01); G01N 33/5008 (2013.01); G01N 33/5011 (2013.01); B01L 3/0241 (2013.01); B01L 2200/027 (2013.01); B01L 2200/10 (2013.01); B01L 2300/08 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/086 (2013.01);
Abstract

The present invention generally relates to a controlled fluidic device to develop spatially complex environments to enhance the rate of evolution in cell populations. The method further provides an enhanced understanding in the emergence, for example, drug resistance during cancer chemotherapy.


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