Andreas Plückthun

Title: Inventor Profile: Andreas Plückthun

Introduction

Andreas Plückthun, an accomplished inventor based in Zurich, Switzerland, has made significant contributions to the field of biotechnology. With a robust portfolio of 10 patents, he has pioneered innovative methods in protein expression and selection processes through his inventions.

Latest Patents

One of his notable inventions is centered around "Cellular high throughput encapsulation for screening or selection." This patented method involves selecting a sequence set from a library of expressed nucleic acid sequences. The process includes providing cells that each contain an expressed nucleic acid sequence, which is converted into a target protein. The encapsulation of these cells is performed by treating them first with a cationic polysaccharide, followed by an anionic polysaccharide. This results in the formation of encapsulated cells. Subsequently, the membrane of these cells is perforated to yield solubilized compartments. These compartments are then contacted with a ligand specific to the target protein, which bears a detectable label. Finally, a subset of solubilized compartments is selected based on the detectable label, allowing for the isolation of the expressed nucleic acid sequences as a selected sequence set.

Career Highlights

Throughout his career, Andreas Plückthun has held key positions at reputable institutions, notably at the University of Zurich and Morphosys AG. His work has not only advanced the understanding of protein interactions but has also been critical in developing methods that enhance drug discovery and biopharmaceutical development.

Collaborations

Andreas has collaborated with distinguished professionals in the field, including Michael Tobias Stumpp and Annemarie Honegger. These collaborations have facilitated a synergistic approach to research, enhancing the innovation process and leading to several successful patent applications.

Conclusion

Andreas Plückthun stands out as a prominent figure in biotechnology, with his innovative approaches to cellular encapsulation and protein selection. His contributions continue to influence research and development within the industry, showcasing the impactful intersection of science and invention.