The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2016
Filed:
Sep. 23, 2008
Fabio Parmeggiani, Seattle, WA (US);
Riccardo Pellarin, Zürich, CH;
Anders Peter Larsen, Salt Lake City, UT (US);
Gautham Varadamsetty, Zürich, CH;
Michael Tobias Stumpp, Geroldswill, CH;
Andreas Plückthun, Zürich, CH;
Fabio Parmeggiani, Seattle, WA (US);
Riccardo Pellarin, Zürich, CH;
Anders Peter Larsen, Salt Lake City, UT (US);
Gautham Varadamsetty, Zürich, CH;
Michael Tobias Stumpp, Geroldswill, CH;
Andreas Plückthun, Zürich, CH;
University of Zurich, Zurich, CH;
Abstract
The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections.