Company Filing History:
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1 out of 5,463 
1 out of 99 Years Active: 2009-2021
Title: Innovations of Alexander MacKerell
Introduction
Alexander MacKerell is a notable inventor based in Baltimore, MD (US). He has made significant contributions to the field of antibiotic research, particularly in the development of small molecule lipid II inhibitors. With a total of five patents to his name, MacKerell's work is at the forefront of combating resistant bacterial strains.
Latest Patents
MacKerell's latest patents focus on newly synthesized derivatives of BAS00127538, which have been discovered to possess antibiotic activity. These compounds are designed to combat resistant bacterial strains effectively. The patents describe compounds and pharmaceutical compositions based on a generic scaffold structure. One of the preferred compounds, 6jc48-1, binds to Lipid II with high affinity and exhibits markedly reduced cytotoxicity compared to BAS00127538. This compound retains its activity against drug-resistant strains and demonstrates stability in plasma, along with improved pharmacokinetic and pharmacodynamics properties. Additionally, it has shown in vivo efficacy in a mouse model of sepsis.
Career Highlights
Throughout his career, MacKerell has worked with prestigious institutions, including the University System of Maryland and the University of Texas System. His research has significantly advanced the understanding of antibiotic mechanisms and the development of new therapeutic agents.
Collaborations
MacKerell has collaborated with notable colleagues such as Jun Hayashi and Erik De Leeuw. These partnerships have contributed to the success of his research and the development of innovative solutions in the field of antibiotics.
Conclusion
Alexander MacKerell's contributions to antibiotic research through his innovative patents highlight his role as a leading inventor in the fight against resistant bacterial strains. His work continues to pave the way for new therapeutic options in medicine.