The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2014
Filed:
Jul. 12, 2010
Alexander Mackerell, Jr., Baltimore, MD (US);
Hong Zhang, Dallas, TX (US);
Andrei Osterman, San Diego, CA (US);
Rohit Kolhatkar, Loves Park, IL (US);
Alexander Mackerell, Jr., Baltimore, MD (US);
Hong Zhang, Dallas, TX (US);
Andrei Osterman, San Diego, CA (US);
Rohit Kolhatkar, Loves Park, IL (US);
University of Maryland, Baltimore, Baltimore, MD (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
Sanford-Burnham Medical Research Institute, La Jolla, CA (US);
Abstract
The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based inhibitor development. To this end, the inventors have identified small molecule compounds that inhibit bacterial target enzymes by interacting with a novel inhibitory binding site on the enzyme while having no effect on functionally equivalent human enzymes.