Alessandro Sette

Title: Innovations by Alessandro Sette

Introduction

Alessandro Sette is a prominent inventor based in San Diego, CA. He has made significant contributions to the field of immunology and vaccine development. With a total of 2 patents, his work focuses on identifying neoantigens and developing potential polypeptide vaccines.

Latest Patents

One of his latest patents is titled "Methods of neoantigen identification." This patent describes systems and methods for identifying neoantigen peptide candidates. Such systems can be utilized to generate engineered immune cells that specifically target neoantigen peptides. Notably, these methods do not require in silico epitope binding prediction algorithms. Additionally, neoantigens can be identified for cancers or tumors with a low mutational burden.

Another significant patent is "Method for identifying useful polypeptide vaccines." This method involves identifying potential polypeptide vaccines against agents such as viruses, bacteria, and parasites. It includes ascertaining a critical binding segment of a first polypeptide known to bind to a specific MHC type. The method evaluates the effect of replacing each amino acid in the critical segment on its binding to the MHC type. Following this evaluation, a protein produced by the agent is scanned for trial amino acid sequences that may serve as good binders to the MHC type. When a promising binding sequence is identified, a polypeptide containing that sequence can be assessed as a synthetic vaccine.

Career Highlights

Alessandro Sette is affiliated with the National Jewish Center for Immunology and Respiratory Medicine. His work at this institution has allowed him to advance research in immunology and contribute to the development of innovative therapeutic strategies.

Collaborations

He has collaborated with notable colleagues such as Soren Buus and Howard M Grey. Their combined expertise has further enhanced the impact of their research in the field.

Conclusion

Alessandro Sette's innovative work in identifying neoantigens and developing polypeptide vaccines showcases his significant contributions to immunology. His patents reflect a commitment to advancing medical science and improving therapeutic options for various diseases.