Location History:
- Baltimore, MD (US) (2013)
- Turin, IT (2001 - 2021)
Company Filing History:
5 out of 3,687 
1 out of 2 
1 out of 97 Years Active: 2001-2021
Title: **Alberto Bardelli: Innovator in Cancer Research**
Introduction
Alberto Bardelli is a prominent inventor based in Turin, Italy. He has made significant contributions to the field of cancer research, holding a total of nine patents that focus on methodologies for improving cancer treatment and understanding tumor biology. His innovative work has had a profound impact on the development of targeted therapies for various cancer types.
Latest Patents
Bardelli's latest patents reflect his deep understanding of genetic mutations associated with cancer. One of his notable inventions is a method of treating cancer which is based on identifying mutations in the extracellular domain III of the epidermal growth factor receptor gene. This invention reveals new mutations that lead to amino acid changes which closely correlate with resistance to therapy regimens that include cetuximab. The patent encompasses peptide sequences and primers essential for detecting these mutations as well as kits designed to predict a patient's response to treatment with cetuximab, particularly benefitting those with metastatic colorectal cancer.
Another significant patent pertains to his mutational analysis of the human tyrosine kinase gene family, where he identified somatic alterations found in approximately 20% of colorectal cancers. The majority of mutations were discovered in genes such as NTRK3, FES, GUCY2F, and an uncharacterized tyrosine kinase gene referred to as MCCK/MLK4. These findings offer a new paradigm for unbiased analysis of signal transduction genes in cancer, paving the way for novel therapeutic interventions targeting these mutations.
Career Highlights
Bardelli’s career is marked by significant research positions and collaborations, notably at The Johns Hopkins University. His diverse experiences in reputable research institutions have equipped him with a wide array of expertise, enabling him to pioneer groundbreaking studies in cancer genetics and personalized medicine.
Collaborations
Throughout his career, Bardelli has collaborated with esteemed researchers such as Bert Vogelstein and Kenneth W. Kinzler. Working alongside these prominent figures in cancer research, he has contributed to innovative studies that advance the understanding of cancer biology and treatment modalities.
Conclusion
In conclusion, Alberto Bardelli's work exemplifies innovation in the medical field, particularly regarding cancer treatment approaches. His nine patents underscore his commitment to improving patient outcomes through better understanding of genetic factors related to cancer. As we continue to navigate the complexities of cancer therapy, the contributions of inventors like Bardelli remain crucial in shaping the future of oncology.