The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Dec. 30, 2014
Fundaciô Institut Mar D'investigacions Mèdiques (Imim), Barcelona, ES;
Alberto Bardelli, Turin, IT;
Sabrina Arena, Turin, IT;
Alberto Bardelli, Turin, IT;
Sabrina Arena, Turin, IT;
Clara Montagut Viladot, Barcelona, ES;
Joan Albanell Mestres, Barcelona, ES;
Ana Rovira Guerin, Barcelona, ES;
Beatriz Bellosillo Paricio, Barcelona, ES;
Alba Dalmases Massegú, Barcelona, ES;
Other;
FUNDACIÓ INSTITUT MAR D'INVESTIGACIONS MEDIQUES (IMIM), Barcelona, ES;
Abstract
The invention relates to new identified mutations in the epidermal growth factor receptor gene, leading to amino acidic changes which highly correlate with the resistance to a therapy regimen comprising cetuximab. The invention includes peptide sequences and primers to detect the mutations, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer.