The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Feb. 15, 2010
Alberto Bardelli, Baltimore, MD (US);
Will Parsons, Ellicott City, MD (US);
Victor Velculescu, Dayton, MD (US);
Kenneth W. Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
Alberto Bardelli, Baltimore, MD (US);
Will Parsons, Ellicott City, MD (US);
Victor Velculescu, Dayton, MD (US);
Kenneth W. Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in -20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.