This inventor holds 4 USPTO granted patents and 14 published patent applications, plus 1 CIPO patent and 1 EPO patent. Top assignee: Diacarta Ltd. Active years: 2013-2021.
Location History:
- Fremont, CA (US) (2013)
- San Ramon, CA (US) (2017 - 2021)
Company Filing History:
Years Active: 2013-2021
Title: Aiguo Zhang: Innovator in DNA Mutation Detection
Introduction
Aiguo Zhang is a prominent inventor based in San Ramon, CA (US). He has made significant contributions to the field of genetic research, particularly in the detection of DNA mutations. With a total of 4 patents, his work has the potential to impact clinical practices in cancer detection and treatment.
Latest Patents
One of Aiguo Zhang's latest patents focuses on DNA mutation detection employing enrichment of mutant polynucleotide sequences and minimally invasive sampling. This invention outlines a method for enriching a target polynucleotide sequence that contains a genetic variation. The method includes providing two primers targeted to the sequence, a target-specific xenonucleic acid clamp oligomer for wildtype sequences, generating multiple amplicons using PCR under specific temperature cycling conditions, and detecting these amplicons. A novel molecule, Xenonucleic Acid (XNA), is introduced for next-generation sequencing (NGS) library preparation. XNA selectively suppresses the amplification of DNA with wildtype alleles while amplifying DNA containing mutant alleles. This allows for the detection of mutants with low allelic frequency without the need for deep sequencing after enrichment through multiplex PCR. The invention investigates 17 actionable mutants related to lung or colorectal cancer diseases at various variant allelic frequencies, significantly improving clinical sensitivity across different sample types.
Career Highlights
Aiguo Zhang is currently associated with Diacarta Ltd, where he continues to advance his research in genetic mutation detection. His innovative approaches have garnered attention in the scientific community, contributing to the development of more effective diagnostic tools.
Collaborations
Throughout his career, Aiguo Zhang has collaborated with notable colleagues, including Michael J Powell and Michael Y Sha. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the impact of his work.
Conclusion
Aiguo Zhang's contributions to DNA mutation detection represent a significant advancement in genetic research. His innovative methods and collaborations continue to pave the way for improved clinical applications in cancer diagnostics.