Adrienne Webster Paton

Title: **Innovative Contributions of Adrienne Webster Paton in the Field of Cytotoxins**

Introduction

Adrienne Webster Paton, an accomplished inventor based in Parkside, Australia, has made significant strides in the realm of biotechnology. With a total of two patents to her name, her work focuses on subtilase cytotoxin proteins and their implications in medical science.

Latest Patents

Adrienne's latest patents showcase her pioneering research. One of her key inventions is the **Subtilase cytotoxin B subunit mutant**. This mutant protein can bind to specific glycans, such as α2-3-linked and α2-6-linked N-glycolylneuraminic acids. The unique characteristic of this mutant SubB protein lies in its deletions within the amino acid sequence TTSTE, which allows it to maintain its binding ability to α2-3-linked glycans while also acquiring the capacity to bind α2-6-linked glycans.

Another important patent is the **Cytotoxin with a subtilase domain**. This invention identifies a new class of bacterial toxins featuring an AB-type structure with a subtilase domain. This cytotoxin exhibits toxicity against Vero cells and shows significant in vivo toxicity in mice across various sites. Notably, a mutation in the serine active residue leads to a remarkable reduction of over 99% in its activity. Furthermore, the protein has been purified, and antibodies for both the A and B subunits have been created, along with the development of ELISA detection methods.

Career Highlights

Adrienne Webster Paton has held influential roles in renowned institutions such as **Adelaide Research & Innovation** and **Griffith University**. Her contributions in these organizations have been instrumental in advancing research and innovation within the fields of biochemistry and molecular biology.

Collaborations

Throughout her career, Adrienne has collaborated with prominent scientists, including **James Cleland Paton** and **Michael Paul Jennings**. These partnerships have fostered a culture of innovation and allowed for the exchange of ideas, ultimately leading to significant advancements in the study of cytotoxins.

Conclusion

Adrienne Webster Paton’s innovative work in developing mutant subtilase cytotoxin proteins and characterizing bacterial toxins underlines her vital role in the scientific community. Her contributions not only enhance our understanding of cytotoxic mechanisms but also pave the way for potential medical applications. With her impressive portfolio of patents and collaborations, Adrienne continues to exemplify the spirit of innovation in biotechnology.