The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2022

Filed:

Nov. 09, 2017
Applicants:

Griffith University, Nathan, AU;

The University of Adelaide, Adelaide, AU;

Inventors:

Michael Paul Jennings, Manly, AU;

Christopher Day, Labrador, AU;

Adrienne Webster Paton, Parkside, AU;

James Cleland Paton, Parkside, AU;

Assignees:

Griffith University, Nathan, AU;

The University of Adelaide, Adelaide, AU;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01); C07K 16/40 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); C07K 16/40 (2013.01); C12Y 304/21062 (2013.01); G01N 33/57492 (2013.01); A61K 38/00 (2013.01); C07K 2317/34 (2013.01); G01N 2400/00 (2013.01);
Abstract

A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having α2-3-linked N-glycolylneuraminic acid and glycans having α2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having α2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having α2-3-linked N-glycolylneuraminic acid.


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