Company Filing History:
3 out of 1,210 
1 out of 1,386 
Years Active: 2009-2015
Title: A Thomas Look: Innovative Mind in Cancer Research
Introduction
A Thomas Look, an esteemed inventor hailing from North Reading, MA, has made significant contributions to the field of cancer research through his innovative work and findings. With a portfolio of three patents, his inventions address critical challenges in cancer treatment, particularly concerning cellular growth and treatment efficacy.
Latest Patents
A Thomas Look's latest patents include groundbreaking methodologies that have the potential to revolutionize cancer therapy. One of his notable inventions is titled "Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, bcl-2 and caspase-3." This invention focuses on treating cancer by utilizing a Chk1 inhibitor that can effectively induce apoptosis in p53-defective cells when administered in conjunction with chemotherapy and/or radiotherapy. Moreover, methods for screening candidates for a Chk1 inhibitor-based cancer treatment regimen are also detailed in this patent.
Another significant patent from Look is related to the discovery of "NOTCH mutations leading to increased receptor signaling." This invention identifies specific regions within the NOTCH-1 receptor whose mutations lead to enhanced receptor signaling associated with uncontrolled cellular growth. By employing agents that interfere with NOTCH-1 activity, such as gamma-secretase inhibitors, this growth can be potentially arrested, providing new diagnostic and treatment avenues for cancer patients.
Career Highlights
Throughout his career, A Thomas Look has been associated with prominent institutions, including the Dana-Farber Cancer Institute and Brigham and Women's Hospital. His work in these organizations has solidified his reputation as an influential figure in cancer research and treatment innovation.
Collaborations
In his pursuit of advancements in cancer therapies, Look has collaborated with talented professionals, including David M. Langenau and Samuel Sidi. These partnerships have facilitated the development of transformative ideas and inventions that address critical healthcare needs.
Conclusion
A Thomas Look's contributions to cancer research and innovation exemplify the crucial role that inventors play in advancing medical science. With a focus on developing solutions that enhance treatment efficacy and patient outcomes, his work continues to inspire new avenues for research and development in oncology.