The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
May. 22, 2009
Jon C. Aster, Lexington, MA (US);
Stephen C. Blacklow, Cambridge, MA (US);
A. Thomas Look, North Reading, MA (US);
Adolfo A. Ferrando, New York, NY (US);
Andrew P. Weng, Vancouver, CA;
Jon C. Aster, Lexington, MA (US);
Stephen C. Blacklow, Cambridge, MA (US);
A. Thomas Look, North Reading, MA (US);
Adolfo A. Ferrando, New York, NY (US);
Andrew P. Weng, Vancouver, CA;
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.