The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2013
Filed:
Feb. 08, 2012
Paul Acton, Quakertown, PA (US);
Zhiqiang an, Ambler, PA (US);
Andrew J. Bett, Lansdale, PA (US);
Robert Breese, Quakertown, PA (US);
Lei Chang, Westmont, IL (US);
Elizabeth Chen Dodson, Souderton, PA (US);
Gene Kinney, Collegeville, PA (US);
William Klein, Winetka, IL (US);
Mary P. Lambert, Glenview, IL (US);
Xiaoping Liang, Collegeville, PA (US);
Paul Shughrue, West Chester, PA (US);
William R. Strohl, Bridgewater, NJ (US);
Kristen Viola, Chicago, IL (US);
Paul Acton, Quakertown, PA (US);
Zhiqiang An, Ambler, PA (US);
Andrew J. Bett, Lansdale, PA (US);
Robert Breese, Quakertown, PA (US);
Lei Chang, Westmont, IL (US);
Elizabeth Chen Dodson, Souderton, PA (US);
Gene Kinney, Collegeville, PA (US);
William Klein, Winetka, IL (US);
Mary P. Lambert, Glenview, IL (US);
Xiaoping Liang, Collegeville, PA (US);
Paul Shughrue, West Chester, PA (US);
William R. Strohl, Bridgewater, NJ (US);
Kristen Viola, Chicago, IL (US);
Northwestern University, Evanston, IL (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.