Company Filing History:
6 out of 2,112 
3 out of 2,405 
2 out of 4,770 
Years Active: 2010-2014
Title: Lei Chang: Innovator in Alzheimer's Disease Research
Introduction
Lei Chang is a prominent inventor based in Westmont, IL (US), known for his significant contributions to the field of Alzheimer's disease research. He holds a total of 6 patents that focus on innovative approaches to detect and treat this debilitating condition. His work has the potential to greatly impact the lives of those affected by Alzheimer's disease.
Latest Patents
One of Lei Chang's latest patents is titled "Anti-ADDL antibodies and uses thereof." This invention relates to antibodies that can differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, commonly known as ADDLs. These antibodies are capable of distinguishing between Alzheimer's disease and control human brain extracts, making them useful in methods for detecting ADDLs and diagnosing Alzheimer's disease. Additionally, these antibodies block the binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation, which are crucial in preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Another significant patent is for "Monoclonal antibodies that target pathological assemblies of amyloid β (Abeta)." This invention discloses antibodies that bind with high specificity to soluble oligomers of amyloid β and outlines methods for employing these antibodies. They can distinguish between Alzheimer's disease and control human brain extracts, identify endogenous Abeta oligomers in Alzheimer's brain slices, and bind to Abeta oligomers on cultured hippocampal cells. Furthermore, these antibodies neutralize endogenous Abeta oligomers and those produced in solution.
Career Highlights
Throughout his career, Lei Chang has worked with esteemed organizations such as Northwestern University and Merck Sharp & Dohme Corporation. His research has been pivotal in advancing the understanding of Alzheimer's disease and developing potential therapeutic strategies.
Collaborations
Lei Chang has collaborated with notable individuals in the field, including William L. Klein and Mary P. Lambert. Their combined expertise has contributed to the success of his research endeavors.
Conclusion
In summary, Lei Chang is a dedicated inventor whose work in Alzheimer's disease research has led to the development of innovative antibodies that hold promise for diagnosis and treatment. His contributions are invaluable in the ongoing fight against this challenging disease.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.