The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Jul. 05, 2005
Mary P Lambert, Glenview, IL (US);
Pauline T. Velasco, Wilmette, IL (US);
Lei Chang, Westmont, IL (US);
Kirsten L. Viola, Chicago, IL (US);
Sara J. Fernandez, Chicago, IL (US);
Pascale N. Lacor, Chicago, IL (US);
Daliya Khuon, Chicago, IL (US);
Yuesong Gong, Evanston, IL (US);
William L. Klein, Winnetka, IL (US);
Grant A. Krafft, Glenview, IL (US);
Mary P Lambert, Glenview, IL (US);
Pauline T. Velasco, Wilmette, IL (US);
Lei Chang, Westmont, IL (US);
Kirsten L. Viola, Chicago, IL (US);
Sara J. Fernandez, Chicago, IL (US);
Pascale N. Lacor, Chicago, IL (US);
Daliya Khuon, Chicago, IL (US);
Yuesong Gong, Evanston, IL (US);
William L. Klein, Winnetka, IL (US);
Grant A. Krafft, Glenview, IL (US);
Northwestern University, Evanston, IL (US);
Acumen Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.