The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2006
Filed:
Jan. 18, 2000
Soloman H. Snyder, Baltimore, MD (US);
Herman Wolosker, Baltimore, MD (US);
Kevin Sheth, Baltimore, MD (US);
Takahashi Masaaki, Baltimore, MD (US);
Jean-pierre Mothet, Baltimore, MD (US);
Roscoe Brady, Jr., Baltimore, MD (US);
Christopher D. Ferris, Baltimore, MD (US);
Soloman H. Snyder, Baltimore, MD (US);
Herman Wolosker, Baltimore, MD (US);
Kevin Sheth, Baltimore, MD (US);
Takahashi Masaaki, Baltimore, MD (US);
Jean-Pierre Mothet, Baltimore, MD (US);
Roscoe Brady, Jr., Baltimore, MD (US);
Christopher D. Ferris, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the 'glycine site' of NMDA receptors. We have purified from rat brain a soluble enzyme that catalyzes the direct racemization of L-serine to D-serine. Purified serine racemase has a molecular weight of 37 kDa and requires pyridoxal 5'-phosphate for its activity. The enzyme is highly selective toward L-serine, failing to racemize any other amino acid tested. We have also identified polynucleotide sequences that encode mammalian, including human, serine racemase. Compounds that modulate the activity of mammalian serine racemase are useful for treating conditions and diseases that involve overstimulation of NMDA receptors, such as stroke and various neurodegenerative diseases.