Baltimore, MD, United States of America

Jean-Pierre Mothet


Average Co-Inventor Count = 7.0

ph-index = 1

Forward Citations = 1(Granted Patents)


Company Filing History:


Years Active: 2006

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1 patent (USPTO):Explore Patents

Title: The Innovations of Jean-Pierre Mothet: A Pioneer in Serine Racemase Research

Introduction: Jean-Pierre Mothet, an innovative inventor based in Baltimore, MD, has made significant contributions to the scientific community with his unique research on the enzyme serine racemase. His patent, which focuses on the conversion of L-serine to D-serine in mammals, adds to our understanding of neurobiology and potential therapeutic applications.

Latest Patents: Mothet holds one notable patent, which pertains to the purification and characterization of mammalian serine racemase. His discovery highlights the role of high levels of D-serine in the mammalian brain, where it serves as an endogenous ligand at the glycine site of NMDA receptors. This research reveals the enzyme's specificity for L-serine and its functional relevance, especially considering its implications for diseases related to NMDA receptor overstimulation, such as stroke and neurodegenerative disorders.

Career Highlights: Working at The Johns Hopkins University, Mothet has risen to prominence through his pioneering work in neurochemistry. His career has been marked by a dedication to understanding the biochemical pathways that underlie critical neurological functions and disorders. The molecular characterization of serine racemase and the identification of its encoding polynucleotide sequences are testaments to his innovative approach to solving complex questions in science.

Collaborations: Throughout his career, Mothet collaborated with esteemed scientists, including Soloman H. Snyder and Herman Wolosker. These partnerships have enhanced his research outcomes and facilitated impactful advancements in the understanding of the roles of amino acids in the brain.

Conclusion: Jean-Pierre Mothet's work has advanced the field of neurobiology, particularly through his patent on mammalian serine racemase. As research continues, the implications of his findings are poised to influence therapeutic strategies for conditions associated with NMDA receptor abnormalities. Mothet exemplifies the spirit of innovation and dedication that drives progress in scientific research and healthcare.

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