Zirui Li

Title: Innovations of Zirui Li in Fusion Protein Development

Introduction

Zirui Li is an accomplished inventor based in Shanghai, China, known for his significant contributions to the field of biopharmaceuticals. He holds three patents that focus on the development of innovative fusion proteins, which have important implications for medical treatments.

Latest Patents

One of his latest patents is titled "Linker peptide for constructing fusion protein." This invention describes a linker peptide that comprises both flexible and rigid peptides. The flexible peptide consists of one or more flexible units made from amino acids such as Gly, Ser, Ala, and Thr. The rigid peptide includes a human chorionic gonadotropin β-subunit carboxy-terminal peptide (CTP) with multiple glycosylation sites. This linker peptide effectively reduces steric hindrance between two fusion molecules, thereby minimizing the loss of polymerization or activity due to improper protein folding. Additionally, the negatively charged, highly sialylated CTP enhances the half-life and bioavailability of the fused protein by resisting renal clearance.

Another notable patent is "Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof." This invention presents a hyperglycosylated recombinant human coagulation factor IX fusion protein that includes a flexible peptide linker and a half-life extending moiety. The fusion protein exhibits biological activity similar to recombinant FIX while offering an extended in vivo activity half-life and reduced immunogenicity, thus improving pharmacokinetics and pharmacodynamics.

Career Highlights

Zirui Li has worked with several prominent companies in the biopharmaceutical sector, including Ampsource Biopharma Shanghai Inc. and Pharmab, Inc. His work has significantly advanced the understanding and application of fusion proteins in therapeutic contexts.

Collaborations

Throughout his career, Zirui Li has collaborated with notable colleagues such as Qiang Li and Si Ruo Chen. These collaborations have contributed to the successful development of his innovative patents.

Conclusion

Zirui Li's work in the field of fusion proteins showcases his expertise and commitment to advancing biopharmaceutical innovations. His patents not only enhance the efficacy of therapeutic proteins but also pave the way for future research and development in this critical area of medicine.