The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Apr. 10, 2017
Ampsource Biopharma Shanghai Inc., Shanghai, CN;
Pharmab, Inc., Shanghai, CN;
YongJuan Gao, Shanghai, CN;
Si Chen, Shanghai, CN;
Zirui Li, Shanghai, CN;
Xiaoping Tu, Shanghai, CN;
Bill Nai-chau Sun, Shanghai, CN;
Qiang Li, Shanghai, CN;
Ampsource Biopharma Shanghai Inc., Shanghai, CN;
Pharmab, Inc., Shanghai, CN;
Abstract
A hyperglycosylated recombinant human coagulation factor IX (FIX) fusion protein, a preparation method therefor, and use thereof. The fusion protein sequentially comprises, from N- to C-terminus, a human FIX, a flexible peptide linker, at least one human chorionic gonadotropin β subunit carboxy-terminal peptide rigid unit, and a half-life extending moiety. The fusion protein has a biological activity similar to that of the recombinant FIX, an extended in vivo activity half-life, and reduced immunogenicity, so as to improve pharmacokinetics and pharmacodynamics.