Company Filing History:
Years Active: 2021
Title: Zimple Matharu: Innovator in Biosensor Technology
Introduction
Zimple Matharu is a prominent inventor based in Davis, CA (US). He has made significant contributions to the field of biosensor technology, particularly in the detection and purification of nucleic acid biomarkers. His innovative work has the potential to revolutionize diagnostics in complex biological fluids.
Latest Patents
Zimple Matharu holds a patent for an integrated electrochemical detection and purification method for nucleic acid biomarkers. This biosensor platform apparatus is designed to detect, purify, and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The patented method employs a two-stage molecular approach. The first stage screens for specific nucleic acid-based biomarkers through electrochemical detection of DNA:RNA hybridization, while also facilitating the removal of remaining complex media constituents. This stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. This identification process can be enhanced with a library of conductance measurements. The methods developed can provide strain-level information that is crucial for identifying antimicrobial resistance in detected pathogens. Additionally, the collection of RNA targets allows for biomarker detection and identification without the need for amplification, providing valuable information about the viability of the sample organism.
Career Highlights
Zimple Matharu is affiliated with the University of California, where he continues to advance his research in biosensor technology. His work has garnered attention for its innovative approach to addressing challenges in the detection of nucleic acid biomarkers.
Collaborations
Zimple collaborates with notable colleagues, including Erkin Seker and Joshua Hihath, who contribute to his research endeavors and enhance the impact of his work in the field.
Conclusion
Zimple Matharu's contributions to biosensor technology exemplify the innovative spirit of modern inventors. His patented methods for detecting and purifying nucleic acid biomarkers hold promise for significant advancements in medical diagnostics.