Location History:
- Edmonton, CA (2009 - 2010)
- Alberta, CA (2010)
Company Filing History:
Years Active: 2009-2010
Title: Innovations of Zi-Hua Jiang
Introduction
Zi-Hua Jiang is a notable inventor based in Edmonton, Canada. He has made significant contributions to the field of immunology and carbohydrate chemistry. With a total of 3 patents to his name, Jiang's work focuses on developing novel compounds that have potential therapeutic applications.
Latest Patents
One of Jiang's latest patents involves the creation of lipid A and other carbohydrate ligand analogs. The core structure of pentaerythritol has been utilized as a replacement for one or both sugars in lipid A, resulting in a series of lipid A analogs. These analogs may vary in terms of the number, nature, and location of negatively charged groups, as well as the lipid chains. The lipid A analogs can serve as lipid A agonists, which are useful as immunostimulatory agents, or as lipid A antagonists, which may aid in the treatment of septic shock. Additionally, a residue of pentaerythritylamine can replace an amino sugar residue in a carbohydrate ligand, generating a series of ligand analogs that are beneficial as haptens and inhibitors of bacterial-host cell adhesion.
Another significant patent by Jiang involves immunostimulatory, covalently lipidated oligonucleotides. These oligonucleotides, which include the CpG dinucleotide unit or its analogs, can be employed as immunostimulatory agents to combat diseases caused by cancer cells or pathogens. They can be used alone or in combination with immunogens and non-immunological agents. Jiang's research highlights lipidated oligonucleotides with unique backbones, those containing fewer than eight nucleotides, and those with multiple CpG dinucleotide segments linked by long internucleoside connections.
Career Highlights
Throughout his career, Zi-Hua Jiang has worked with various companies, including Oncothyreon Inc. and Biomira, Inc. His innovative research has contributed to advancements in immunology and therapeutic development.
Collaborations
Jiang has collaborated with notable professionals in his field, including Rao R Koganty and Damayanthi Yalamati.
Conclusion
Zi-Hua Jiang's contributions to the field of immunology and carbohydrate chemistry are noteworthy. His innovative patents and collaborations reflect his commitment to advancing scientific knowledge and developing new therapeutic agents.