The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2009
Filed:
Nov. 15, 2000
Zi-hua Jiang, Edmonton, CA;
Mimi Bach, Edmonton, CA;
Damayanthi Yalamati, Edmonton, CA;
Rao Koganty, Edmonton, CA;
Michael Longenecker, Edmonton, CA;
Zi-Hua Jiang, Edmonton, CA;
Mimi Bach, Edmonton, CA;
Damayanthi Yalamati, Edmonton, CA;
Rao Koganty, Edmonton, CA;
Michael Longenecker, Edmonton, CA;
Biomira, Inc., Edmonton, Alberta, CA;
Abstract
New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found in nature. Also, novel disaccharide Lipid-A structures (2) that incorporate novel contingents of uniform lipids and where R, Rand Rare the same substitution group of structure (III) were synthesized. Liposome formulations containing totally synthetic components such as synthetic Lipid-A and synthetic lipopeptide derived from tumor-associated MUC1 mucin are described along with their therapeutic utility. Comparative test results of immunostimulating properties and toxicity of Lipid-A analogs (1) and (2) are included.