Location History:
- Nashville, TN (US) (2018 - 2020)
- Lake Bluff, IL (US) (2021 - 2023)
Company Filing History:
Years Active: 2018-2025
Title: Zhiguo Bian: Innovator in Pharmaceutical Chemistry
Introduction
Zhiguo Bian is a prominent inventor based in Nashville, TN (US), known for his significant contributions to pharmaceutical chemistry. He holds a total of 9 patents, focusing on innovative compounds that target critical proteins involved in various diseases, particularly cancer.
Latest Patents
Among his latest patents, one notable invention is the development of substituted indole Mcl-1 inhibitors. This invention provides compounds that inhibit the activity of the anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The invention also includes pharmaceutical compositions and methods for using these compounds to treat diseases characterized by the over-expression or dysregulation of Mcl-1 protein. Another significant patent involves pyrimidines for degrading Bruton's tyrosine kinase, which presents compounds useful as agents in the treatment of chronic lymphocytic leukemia (CLL).
Career Highlights
Zhiguo Bian has worked with esteemed organizations such as Vanderbilt University and AbbVie Inc. His work in these institutions has allowed him to advance his research and contribute to the field of pharmaceutical sciences.
Collaborations
Throughout his career, Bian has collaborated with notable colleagues, including Taekyu Lee and Edward T Olejniczak. These collaborations have further enriched his research and innovation efforts.
Conclusion
Zhiguo Bian's work exemplifies the impact of innovative research in pharmaceutical chemistry. His patents and collaborations continue to pave the way for advancements in treatments for critical health conditions.