The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
Sep. 20, 2013
Applicant:
Vanderbilt University, Nashville, TN (US);
Inventors:
Taekyu Lee, Brentwood, TN (US);
Nicholas F. Pelz, Nashville, TN (US);
Johannes Belmar, Nashville, TN (US);
Zhiguo Bian, Nashville, TN (US);
Edward T. Olejniczak, Nashville, TN (US);
Stephen W. Fesik, Nashville, TN (US);
Brian A. Chauder, Smyrna, TN (US);
Assignee:
Vanderbilt University, Nashville, TN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/85 (2006.01); C07D 405/10 (2006.01); C07D 413/10 (2006.01); C07D 401/10 (2006.01); A61K 31/381 (2006.01); A61K 31/343 (2006.01); A61K 31/404 (2006.01); A61K 31/4709 (2006.01); A61K 31/422 (2006.01); A61K 31/4439 (2006.01); A61K 31/4155 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 333/70 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 209/42 (2006.01);
U.S. Cl.
CPC ...
C07D 307/85 (2013.01); A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61K 31/404 (2013.01); A61K 31/4155 (2013.01); A61K 31/422 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 209/42 (2013.01); C07D 333/70 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/04 (2013.01); C07D 405/10 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01);
Abstract
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.