This inventor holds 1 USPTO granted patent. Top assignee: 3-Dimensional Pharmaceuticals, Inc.. Active years: 2000.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2000
Title: Zhengdong Wu - Innovator in Combinatorial Libraries
Introduction
Zhengdong Wu is a notable inventor based in Exton, PA (US). He has made significant contributions to the field of combinatorial chemistry, particularly through his innovative patent related to aminobenzenedicarboxylic acid-based libraries. His work has implications for pharmaceutical development and biological research.
Latest Patents
Zhengdong Wu holds a patent for "Aminobenzenedicarboxylic acid-based combinatorial libraries." This invention provides a library of compounds, each comprised of a common aminobenzenedicarboxylic acid core structure that serves as a template for synthesizing approximately 10^1 - 10^6 compounds which are analogs of the scaffold. The library is employed to study ligand binding by biological receptors, such as enzymes, G-protein coupled receptors, and membrane channels. Certain individual compounds within the library selectively bind and inhibit the action of trypsin-like serine proteases. The invention also relates to combinatorial synthetic methods for making such libraries of compounds and novel scaffold-modified solid supports, particularly scaffold-modified polymer resins. Furthermore, it includes methods for screening compounds made according to the synthetic methods disclosed, which comprise using the compounds in suitable assays developed for detecting their utility as pharmaceutical agents.
Career Highlights
Zhengdong Wu is associated with 3-Dimensional Pharmaceuticals, Inc., where he has been instrumental in advancing research and development in combinatorial chemistry. His innovative approach has positioned him as a key figure in the field.
Collaborations
Zhengdong Wu has collaborated with notable colleagues, including Todd L Graybill and Nalin L Subasinghe. Their combined expertise has contributed to the success of various projects within their organization.
Conclusion
Zhengdong Wu's contributions to the field of combinatorial libraries highlight his innovative spirit and dedication to advancing pharmaceutical research. His work continues to influence the development of new therapeutic agents.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile