Location History:
- Malden, MA (US) (2016)
- Beijing, CN (2020 - 2023)
Company Filing History:
1 out of 2,963 
1 out of 8,373 
1 out of 98 Years Active: 2016-2023
Title: Innovations and Contributions of Inventor Zhen Xie
Introduction
Zhen Xie is a prominent inventor based in Beijing, China. He has made significant contributions to the fields of gene editing and renewable energy technology. With a total of four patents to his name, his work reflects a commitment to advancing scientific knowledge and practical applications.
Latest Patents
One of Zhen Xie's latest patents is the engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA. This invention offers programmable and precise regulation of Cas9 functions by utilizing a set of compact Cas9 derivatives. These derivatives are created by deleting conserved HNH and/or REC-C domains based on structural information across variant class 2 CRISPR effectors. Additionally, he has developed a novel strategy for engineering the dimeric gRNA-guided nuclease by splitting the mini-dSaCas9 and fusing the FokI domain right after the split point. This approach aims to increase on-target DNA cleavage efficiency while potentially reducing off-target effects. By combining the optimized gRNA expression cassette and downsized SaCas9 derivatives, the entire CRISPR/Cas system can be loaded into a single AAV virus, making it particularly appealing for biomedical applications that require safe and efficient in vivo delivery.
Another significant patent is the yaw calibration method and system for wind turbines. This disclosure proposes a calibration method that includes establishing a cylindrical coordinate graph of wind resource distribution based on historical wind farm operation data. The method determines a wind direction interval of main inflow wind conditions and calculates the effective value of active power for each wind speed sub-interval. It also establishes a yaw error calibration value lookup table to enhance the efficiency of wind turbines.
Career Highlights
Zhen Xie has worked at notable institutions, including Harvard College. His experience in these environments has allowed him to collaborate with leading experts in his field and contribute to groundbreaking research.
Collaborations
Throughout his career, Zhen Xie has collaborated with esteemed colleagues such as Ron Weiss and Yaakov Benenson. These partnerships have further enriched his research and innovation efforts.
Conclusion
Zhen Xie's contributions to gene editing and renewable energy technology exemplify the impact of innovative thinking in addressing contemporary challenges. His patents reflect a dedication to advancing science and improving practical applications in various fields.