Zaverio M Ruggeri

Title: Zaverio M Ruggeri: Innovator in Anticoagulant Therapeutics

Introduction

Zaverio M Ruggeri is a prominent inventor based in La Jolla, CA (US). He has made significant contributions to the field of anticoagulant therapeutics, holding a total of 8 patents. His work focuses on innovative methods for evaluating the efficacy of anticoagulant therapies, which are crucial for patient care in various medical settings.

Latest Patents

Among his latest patents, Ruggeri has developed compositions and methods for evaluating anticoagulant therapeutic efficacy. This method involves providing a blood sample, perfusing it over a surface coated with collagen or immobilized rTF, measuring platelet aggregation and fibrin deposition, and assessing the therapeutic efficacy based on the volume of platelet aggregates and/or deposited fibrin. Another notable patent is for a thrombin generation assay, which measures thrombin generated in a blood sample. This assay includes incubating the blood sample with TF, FIXa, and CaCl2, and determining bleeding risk based on the amount of coagulation factor VIII in the sample.

Career Highlights

Ruggeri has had a distinguished career, working with esteemed institutions such as The Scripps Research Institute and Scripps Clinic and Research Foundation. His research has significantly advanced the understanding of blood coagulation and anticoagulant therapies.

Collaborations

Throughout his career, Ruggeri has collaborated with notable colleagues, including Jerry L Ware and Theodore S Zimmerman. These collaborations have further enriched his research and contributions to the field.

Conclusion

Zaverio M Ruggeri's innovative work in anticoagulant therapeutics has made a lasting impact on medical science. His patents and research continue to influence the development of effective treatments for patients at risk of bleeding disorders.