The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Aug. 27, 2021
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Zaverio Ruggeri, La Jolla, CA (US);
Wolfram Ruf, San Diego, CA (US);
Yuichi Kamikubo, San Diego, CA (US);
Assignee:
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/745 (2006.01); A61P 7/02 (2006.01); C12N 9/64 (2006.01); G01N 33/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/745 (2013.01); A61P 7/02 (2018.01); C12N 9/644 (2013.01); C12Y 304/21022 (2013.01); G01N 33/86 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01);
Abstract
In various embodiments, disclosed herein are methods of assessing therapeutic efficacy of an anticoagulant. Preferably, the method comprising providing a blood sample; perfusing the blood sample over a surface coated with collagen or immobilized rTF; measuring platelet aggregation and fibrin deposition on the surface coated with collagen or immobilized rTF; and assessing therapeutic efficacy of the anticoagulant based on the volume of platelet aggregates and/or deposited fibrin.