Zaiwei Zong

Title: Innovations of Zaiwei Zong in Nucleoside Compound Preparation

Introduction

Zaiwei Zong is a notable inventor based in Nanjing, China. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the preparation of nucleoside compounds. His innovative methods have the potential to enhance industrial applications in this area.

Latest Patents

Zaiwei Zong holds a patent for a method for preparing a β-nucleoside compound. This method involves a one-pot process that includes several key steps. First, a silylation reaction of a nitrogenous base or its analogue is performed in the presence of TMSOTf, resulting in a protected nitrogenous base. Next, a direct glycosylation reaction occurs without isolating the reaction liquid, using a five- or six-membered ring saccharide or its derivative. Finally, a deprotection reaction yields the β-nucleoside compound. This method significantly increases the yield of materials in β-configuration and is characterized by its simplicity, energy conservation, and environmental protection.

Career Highlights

Zaiwei Zong is associated with Jiangsu Aosaikang Pharmaceutical Co., Ltd., where he applies his expertise in pharmaceutical innovations. His work focuses on developing efficient methods for synthesizing important chemical compounds that can be utilized in various medical applications.

Collaborations

Zaiwei Zong collaborates with talented coworkers, including Qian Zhao and Ruifeng Yang. Their combined efforts contribute to advancing research and development in the pharmaceutical industry.

Conclusion

Zaiwei Zong's innovative approach to preparing β-nucleoside compounds showcases his commitment to enhancing pharmaceutical processes. His contributions are poised to make a significant impact in the field of drug development and production.